CMPF: Class-switching minimized pathfinding in metabolic networks
نویسندگان
چکیده
منابع مشابه
Metabolic PathFinding: inferring relevant pathways in biochemical networks
Our knowledge of metabolism can be represented as a network comprising several thousands of nodes (compounds and reactions). Several groups applied graph theory to analyse the topological properties of this network and to infer metabolic pathways by path finding. This is, however, not straightforward, with a major problem caused by traversing irrelevant shortcuts through highly connected nodes,...
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We investigate the properties of ensembles of neural networks, in which each network in the ensemble is constructed using a perturbed version of the training data. The perturbation consists in switching the class labels of a subset of training examples selected at random. Experiments on several UCI and synthetic datasets show that these class-switching ensembles can obtain improvements in class...
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OBJECTIVE 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is a metabolite produced endogenously from dietary sources of furan fatty acids. The richest source of furan fatty acids in human diet is fish. CMPF was recently shown to be elevated in fasting plasma in individuals with gestational diabetes and type 2 diabetes, and mechanistically high level of CMPF was linked to β cell dysfunc...
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Antibody class switching emerged in evolutionary history when bony fish grew legs and became amphibians. On page 733, Barreto and colleagues show that the switch-inducing enzyme AID (activation-induced cytidine deaminase) is in working order in bony fish, suggesting that the evolution of the switch reaction had to wait for the acquisition of some other component. Bony fish produce antibodies bu...
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Considering the network structure is one of the new approaches in studying stochastic PERT networks (SPN). In this paper, planar networks are studied as a special class of networks. Two structural reducible mechanisms titled arc contraction and deletion are developed to convert any planar network to a series-parallel network structure.
In series-parallel SPN, the completion time distribution...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2012
ISSN: 1471-2105
DOI: 10.1186/1471-2105-13-s17-s17